Headache and cognitive profile in children: a cross-sectional controlled study

J Headache Pain. 2010 Feb;11(1):45-51. doi: 10.1007/s10194-009-0165-8. Epub 2009 Oct 20.

Abstract

We investigated whether children affected by tension-type headache and migraine without aura, compared with a healthy control group that was matched by age, culturally and socioeconomically display a diverse intellectual functioning and have a separate "cognitive profile". A cross-sectional study was conducted from January 2006 to November 2008 at "Sapienza University" in Rome. A total of 134 children were diagnosed as being affected by either migraine without aura (93) or tension-type headache (41). On the basis of our exclusion/inclusion criteria, we enrolled 82 of these 134 children, 63 of whom were affected by migraine without aura and 19 by tension-type headache. On entry, cognitive functions were assessed in both the affected subjects and the control group by the Wechsler Intelligence Scale for Children-revised. Significant differences were found between the headache and control groups in the mean total intelligence quotient and verbal intelligence quotient scores (p < 0.001). Significant negative correlations were found between the total intelligence quotient, verbal intelligence quotient, performance intelligence quotient and the frequency of attacks (r = -0.55 and p < 0.001, r = -0.61 and p < 0.001, r = -0.29 and p < 0.01, respectively), as well as between the total intelligence quotient score and the age at headache onset (r = 0.234, p < 0.05). Our results suggest that the cognitive profile of children affected by headache should be assessed at the first child neurology outpatient observation. From a therapeutic point of view, although within a normal range, the abilities most likely to be less brilliant in such children are verbal skills.

MeSH terms

  • Adolescent
  • Analysis of Variance
  • Case-Control Studies
  • Child
  • Cognition Disorders / etiology*
  • Comprehension / physiology
  • Cross-Sectional Studies
  • Female
  • Humans
  • Intelligence / physiology
  • Linear Models
  • Male
  • Migraine without Aura / complications*
  • Neuropsychological Tests
  • Retrospective Studies
  • Tension-Type Headache / complications*
  • Verbal Behavior / physiology
  • Wechsler Scales