Diversity synthesis of N-substituted 2-amino-1,6-naphthyridine derivatives under microwave irradiation

Zheng-Guo Han; Chun-Bao Miao; Feng Shi; Ning Ma; Ge Zhang; Shu-Jiang Tu

doi:10.1021/cc900030e

Diversity synthesis of N-substituted 2-amino-1,6-naphthyridine derivatives under microwave irradiation

J Comb Chem. 2010 Jan-Feb;12(1):16-9. doi: 10.1021/cc900030e.

Authors

Zheng-Guo Han¹, Chun-Bao Miao, Feng Shi, Ning Ma, Ge Zhang, Shu-Jiang Tu

Affiliation

¹ School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu, PR China.

PMID: 19852499
DOI: 10.1021/cc900030e

Abstract

A sequential three-component reaction of 3,5-diarylidenepiperidin-4-one, malononitrile, and amine (such as aromatic amine, cyclopropanamine, and NH(4)OAc) in acetic acid under microwave irradiation has been developed. In this one-pot reaction, a series of new N-substituted 2-amino-1,6-naphthyridine derivatives were synthesized with excellent yields. This method has the advantages of operational simplicity and increased safety for small-scale fast synthesis of N-aryl 2-amino-1,6-naphthyridines for biomedical screening.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Combinatorial Chemistry Techniques / methods*
Microwaves*
Naphthyridines / chemical synthesis*
Radiation

Substances

Naphthyridines