Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

Behav Brain Res. 2010 Mar 5;207(2):508-11. doi: 10.1016/j.bbr.2009.10.020. Epub 2009 Oct 22.

Abstract

In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R(+/+)), both heterozygous (D4R(+/-)) and knockout (D4R(-/-)) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cocaine / administration & dosage
  • Cocaine / pharmacology*
  • Conditioning, Operant / drug effects*
  • Conditioning, Operant / physiology*
  • Dopamine Uptake Inhibitors / administration & dosage
  • Dopamine Uptake Inhibitors / pharmacology*
  • Food*
  • Heterozygote
  • Male
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Receptors, Dopamine D4 / deficiency
  • Receptors, Dopamine D4 / genetics
  • Receptors, Dopamine D4 / metabolism*
  • Self Administration

Substances

  • Dopamine Uptake Inhibitors
  • Receptors, Dopamine D4
  • Cocaine