Abstract
Elite controllers or suppressors are untreated human immunodeficiency virus type 1 (HIV-1)-infected patients who maintain undetectable viral loads. In this study, we show that most elite suppressors do not experience significant changes in T cell counts over a 10-year period. Interestingly, treatment of an elite suppressor with highly active antiretroviral therapy (HAART) led to a marked decrease in immune activation.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adult
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Antiretroviral Therapy, Highly Active / adverse effects
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Antiviral Agents / adverse effects
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Antiviral Agents / pharmacology*
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Antiviral Agents / therapeutic use*
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CD4 Lymphocyte Count
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Cohort Studies
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HIV Infections / drug therapy*
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HIV Infections / immunology*
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Humans
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Lymphocyte Count
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Middle Aged
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T-Lymphocytes / drug effects*
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T-Lymphocytes / immunology
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Viral Load / drug effects