Abstract
Apoptosis, the programmed cell death, is a highly regulated process, necessary for normal development and homeostasis of the functions of organisms. The Bcl-2 inhibitors BH3I-1 and BH3I-2 were used as lead compounds to find possible Bcl-2 or Bcl-X(L) inhibitors by using computer-assisted screening with our in-house database, containing more than four million commercially available molecules. Identified compounds were further investigated regarding their possible application as a drug.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apoptosis / drug effects
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Benzamides / chemistry*
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Benzamides / pharmacology
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Cell Line
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Computational Biology
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Computer Simulation*
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Databases, Factual
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Humans
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Models, Chemical*
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Molecular Weight
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Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors
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Thiazoles / chemistry*
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Thiazoles / pharmacology
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Thiazolidinediones
Substances
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3-iodo-5-chloro-N-(2-chloro-5-((4-chlorophenyl)sulphonyl)phenyl)-2-hydroxybenzamide
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5-(4-bromobenzylidene)-alpha-isopropyl-4-oxo-2-thioxo-3-thazolidineacetic acid
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Benzamides
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Proto-Oncogene Proteins c-bcl-2
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Thiazoles
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Thiazolidinediones