An important part of evidence-based practice is to identify the best and most current research evidence to guide clinical practice. The purpose of this paper is to propose the use of the 5-S model by Haynes (2006) as a principled approach for navigating evidence-based information sources related to interventions in augmentative and alternative communication (AAC). The 5-S model is a pyramid that is used from the top down, beginning with systems followed by summaries, synopses, syntheses, and studies. The 5-S model is described along with relevant evidence-based information sources in AAC, and subsequently illustrated with a case scenario. Following the 5-S model may enable practitioners to identify the best and most current research evidence.