Molecular iodine promoted synthesis of new pyrazolo[3,4-d]pyrimidine derivatives as potential antibacterial agents

Mehdi Bakavoli; Ghodsieh Bagherzadeh; Maryam Vaseghifar; Ali Shiri; Mehdi Pordel; Mansour Mashreghi; Parvaneh Pordeli; Maryam Araghi

doi:10.1016/j.ejmech.2009.10.051

Molecular iodine promoted synthesis of new pyrazolo[3,4-d]pyrimidine derivatives as potential antibacterial agents

Eur J Med Chem. 2010 Feb;45(2):647-50. doi: 10.1016/j.ejmech.2009.10.051. Epub 2009 Nov 6.

Authors

Mehdi Bakavoli¹, Ghodsieh Bagherzadeh, Maryam Vaseghifar, Ali Shiri, Mehdi Pordel, Mansour Mashreghi, Parvaneh Pordeli, Maryam Araghi

Affiliation

¹ Department of Chemistry, School of Sciences, Ferdowsi University of Mashhad, Vakilabad Blvd 91775-1436 Mashhad, Iran. mbakavoli@yahoo.com

PMID: 19926175
DOI: 10.1016/j.ejmech.2009.10.051

Abstract

Iodocyclization of 5-amino-1-(2,4-dinitrophenyl)-1H-4-pyrazolcarboxamides with aromatic aldehydes gave a new series of pyrazolo[3,4-d]pyrimidine derivatives in a single step and their antibacterial activity comparable to Streptomycin as reference drug was evaluated.

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Bacteria / drug effects
Catalysis
Cyclization
Iodine / chemistry*
Oxidation-Reduction
Pyrimidines / chemical synthesis*
Pyrimidines / chemistry
Pyrimidines / pharmacology*

Substances

Anti-Bacterial Agents
Pyrimidines
Iodine