[Granulocytic sarcoma, a diagnostic challenge: 3 pediatric cases]

Arch Pediatr. 2010 Feb;17(2):149-53. doi: 10.1016/j.arcped.2009.10.018. Epub 2009 Nov 27.
[Article in French]

Abstract

Granulocytic sarcoma (GS) is a rare extramedullary tumor frequently associated with acute myeloblastic leukemia (AML). We report 3 cases of pediatric granulocytic sarcomas with various locations: skin, orbit, and bowel. Cases 1 and 2 were associated with AML; case 3 was isolated. In all 3 cases, the diagnosis was delayed or initially missed. Pathology and immunohistochemistry data identified the disease. GS is treated with chemotherapy, like AML. The prognosis of GS seems better than that of isolated AML.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols
  • Biopsy
  • Bone Marrow / pathology
  • Bone Marrow Transplantation
  • Child, Preschool
  • Combined Modality Therapy
  • Diagnostic Errors
  • Facial Neoplasms / diagnosis*
  • Facial Neoplasms / drug therapy
  • Facial Neoplasms / pathology
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Intestinal Neoplasms / diagnosis*
  • Intestinal Neoplasms / drug therapy
  • Intestinal Neoplasms / pathology
  • Intestine, Small*
  • Leukemia, Biphenotypic, Acute / diagnosis
  • Leukemia, Biphenotypic, Acute / drug therapy
  • Leukemia, Biphenotypic, Acute / pathology
  • Leukemia, Myeloid, Acute / diagnosis*
  • Leukemia, Myeloid, Acute / drug therapy
  • Leukemia, Myeloid, Acute / pathology
  • Male
  • Neoplasms, Multiple Primary / diagnosis*
  • Neoplasms, Multiple Primary / drug therapy
  • Neoplasms, Multiple Primary / pathology
  • Orbital Neoplasms / diagnosis*
  • Orbital Neoplasms / drug therapy
  • Orbital Neoplasms / pathology
  • Sarcoma, Myeloid / diagnosis*
  • Sarcoma, Myeloid / drug therapy
  • Sarcoma, Myeloid / pathology
  • Skin Neoplasms / diagnosis*
  • Skin Neoplasms / drug therapy
  • Skin Neoplasms / pathology
  • Tomography, X-Ray Computed