The peptide pyroGlu-Gln-Gly-Ser-Asn, isolated from mouse liver, inhibits growth of rat hepatoma cells in vitro

Carcinogenesis. 1991 Feb;12(2):207-10. doi: 10.1093/carcin/12.2.207.

Abstract

The peptide pyroGlu-Gln-Gly-Ser-Asn, recently isolated from mouse liver, inhibited DNA synthesis and proliferation in vitro of MH1C1 cells, a rat clonal strain derived from a Morris transplantable hepatoma. Both the biological peptide isolated from mouse liver and the synthetic homolog showed bell-shaped dose-response curves. Maximal inhibition (approximately 50%) was observed at two separate dose ranges: one at 10(-7)-10(-10) M, and one at 10(-14)-10(-15) M.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Division / drug effects
  • DNA / biosynthesis
  • Dose-Response Relationship, Drug
  • Liver / chemistry
  • Liver / cytology
  • Liver / drug effects*
  • Liver / metabolism
  • Liver Neoplasms, Experimental / drug therapy
  • Liver Neoplasms, Experimental / pathology*
  • Mice
  • Molecular Sequence Data
  • Neoplasm Transplantation
  • Oligopeptides / pharmacology*
  • Peptides / isolation & purification
  • Peptides / pharmacology*
  • Pyrrolidonecarboxylic Acid / analogs & derivatives
  • Rats
  • Time Factors
  • Tumor Cells, Cultured

Substances

  • Oligopeptides
  • Peptides
  • pyroglutamyl-glutaminyl-glycyl-seryl-asparagine
  • DNA
  • Pyrrolidonecarboxylic Acid