Frequent allelic loss of Dkk-1 locus (10q11.2) is related with low distant metastasis and better prognosis in head and neck squamous cell carcinomas

Cancer Invest. 2010 Jan;28(1):103-10. doi: 10.3109/07357900903095680.

Abstract

Head and neck squamous cell carcinoma (HNSCC) is a frequently occurring cancer worldwide. Dickkopf (Dkk)-1 gene is suggested to function as tumor suppressor gene (TSG) in several kinds of malignancies. In this study, we performed loss of heterozygosity (LOH) analysis of Dkk-1 and examined the correlation between LOH status and clinicopathological parameters for the first time. A pretty high LOH ratio (50%) was detected. Interestingly, in the cases with Dkk-1 retention group showed less distant metastasis and a tendency of longer disease free survival. These results indicate that Dkk-1 can play a role in HNSCC carcinogenesis and it may also be related to distant metastasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Carcinoma, Squamous Cell / genetics*
  • Carcinoma, Squamous Cell / mortality
  • Carcinoma, Squamous Cell / secondary
  • Carcinoma, Squamous Cell / therapy
  • Chromosomes, Human, Pair 10*
  • Disease-Free Survival
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Gene Frequency
  • Head and Neck Neoplasms / genetics*
  • Head and Neck Neoplasms / mortality
  • Head and Neck Neoplasms / secondary
  • Head and Neck Neoplasms / therapy
  • Humans
  • Intercellular Signaling Peptides and Proteins / genetics*
  • Kaplan-Meier Estimate
  • Loss of Heterozygosity*
  • Male
  • Microsatellite Repeats
  • Middle Aged
  • Time Factors
  • Treatment Outcome

Substances

  • DKK1 protein, human
  • Intercellular Signaling Peptides and Proteins