Abstract
This study examined bacteria-immune interactions in a mouse model possessing microbiota-dependent immune regulatory features similar to those occurring in human atopy, colitis, and immune regulation. Associations between the abundance of several bacterial phylotypes and immunoregulatory target cell types were identified, suggesting that they may play a role in these phenotypes.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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B-Lymphocytes / immunology*
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Bacteria / classification
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Bacteria / genetics
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Bacteria / isolation & purification*
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Colitis / immunology
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Colitis / microbiology
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DNA, Bacterial / metabolism
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Humans
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Immunity, Innate
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Intestines / immunology
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Intestines / microbiology
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Lymphocyte Activation / immunology
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Mice, Transgenic
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Natural Killer T-Cells / immunology*
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RNA, Ribosomal, 16S / metabolism
Substances
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DNA, Bacterial
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RNA, Ribosomal, 16S