Immunotherapy of rheumatoid arthritis targeting inflammatory cytokines and autoreactive T cells

Arch Immunol Ther Exp (Warsz). 2010 Feb;58(1):27-36. doi: 10.1007/s00005-009-0058-1. Epub 2010 Jan 5.

Abstract

Rheumatoid arthritis is a chronic disorder for which there is no known cure. Concentrating on specific elements of the abnormal immune response that characterizes the disease, scientists are reaching into biotechnology's bag of tricks to develop immunotherapeutic techniques. This paper will present some advances in the immunotherapy of rheumatoid arthritis targeting inflammatory cytokines and autoreactive T cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antibodies, Monoclonal / therapeutic use
  • Antigens, CD / therapeutic use
  • Arthritis, Rheumatoid / immunology*
  • Arthritis, Rheumatoid / therapy*
  • CTLA-4 Antigen
  • Collagen Type II / therapeutic use
  • Cytokines / immunology
  • Humans
  • Immune Tolerance
  • Immunotherapy*
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / transplantation

Substances

  • Antibodies, Monoclonal
  • Antigens, CD
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • Collagen Type II
  • Cytokines