Biology of basal cell carcinoma (Part II)

J Am Acad Dermatol. 1991 Feb;24(2 Pt 1):161-75. doi: 10.1016/0190-9622(91)70022-t.

Abstract

Host-tumor relationships involve several factors that can enhance or suppress neoplastic growth. This second part of a review of basal cell carcinoma biology examines the role that hormones, cytokines, local and systemic immunity, congenital and genetic syndromes, and environmental factors play in the development of this neoplasm. Theories of etiology and pathogenesis are discussed, and transplantation and cell culture techniques used to study this cancer are explored. Valuable second-line therapies for treatment of multiple tumors are reviewed, and important areas of present and future research are emphasized.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carcinoma, Basal Cell* / etiology
  • Carcinoma, Basal Cell* / immunology
  • Carcinoma, Basal Cell* / pathology
  • Carcinoma, Basal Cell* / therapy
  • Cells, Cultured
  • Humans
  • Immunotherapy, Active
  • Photochemotherapy
  • Research
  • Retinoids / administration & dosage
  • Retinoids / therapeutic use
  • Skin Neoplasms* / etiology
  • Skin Neoplasms* / immunology
  • Skin Neoplasms* / pathology
  • Skin Neoplasms* / therapy

Substances

  • Retinoids