Polymorphisms in MMP-2 and MMP-9 promoter regions are associated with endometriosis

Merli Saare; Merit Lamp; Tanel Kaart; Helle Karro; Ülle Kadastik; Andres Metspalu; Maire Peters; Andres Salumets

doi:10.1016/j.fertnstert.2009.12.024

Polymorphisms in MMP-2 and MMP-9 promoter regions are associated with endometriosis

Fertil Steril. 2010 Sep;94(4):1560-1563. doi: 10.1016/j.fertnstert.2009.12.024. Epub 2010 Jan 25.

Authors

Merli Saare¹, Merit Lamp², Tanel Kaart³, Helle Karro⁴, Ülle Kadastik⁵, Andres Metspalu⁶, Maire Peters⁷, Andres Salumets⁸

Affiliations

¹ Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia. Electronic address: merli.saare@ut.ee.
² Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia.
³ Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Tartu, Estonia.
⁴ Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia; Tartu University Hospital's Women's Clinic, Tartu, Estonia.
⁵ Tartu University Hospital's Women's Clinic, Tartu, Estonia.
⁶ Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia; Estonian Biocenter, Tartu, Estonia; Estonian Genome Project, University of Tartu, Tartu, Estonia.
⁷ Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia; Estonian Biocenter, Tartu, Estonia.
⁸ Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia; Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia; Nova Vita Clinic, Center for Infertility Treatment and Medical Genetics, Viimsi, Estonia.

PMID: 20100617
DOI: 10.1016/j.fertnstert.2009.12.024

Abstract

In this case-control study, we investigated the potential associations of MMP-2 and MMP-9 gene promoter region polymorphisms as well as MMP-2 promoter haplotypes with susceptibility to endometriosis in women of caucasian origin. The results demonstrated that polymorphisms in MMP-2 (-735 C/T) and MMP-9 (-1562 C/T) were associated with elevated risk of endometriosis and that certain MMP-2 promoter haplotypes were more common in control group.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Case-Control Studies
Endometriosis / genetics*
Female
Genetic Linkage
Genetic Predisposition to Disease
Humans
Matrix Metalloproteinase 2 / genetics*
Matrix Metalloproteinase 9 / genetics*
Middle Aged
Polymorphism, Genetic*
Promoter Regions, Genetic* / genetics
Uterine Diseases / genetics*
Young Adult

Substances

Matrix Metalloproteinase 2
Matrix Metalloproteinase 9