Neurocognitive function of patients with severe combined immunodeficiency

Ami J Shah; Donald B Kohn

doi:10.1016/j.iac.2009.10.003

Neurocognitive function of patients with severe combined immunodeficiency

Immunol Allergy Clin North Am. 2010 Feb;30(1):143-51. doi: 10.1016/j.iac.2009.10.003.

Authors

Ami J Shah¹, Donald B Kohn

Affiliation

¹ Division of Research Immunology/Bone Marrow Transplantation, Department of Pediatrics, The Saban Research Institute, Childrens Hospital Los Angeles, University of Southern California Keck School of Medicine, 4650 Sunset Boulevard, MS # 62, Los Angeles, CA 90027, USA. Ashah@chla.usc.edu

PMID: 20113891
DOI: 10.1016/j.iac.2009.10.003

Abstract

Hematopoietic stem cell transplantation (HSCT) has offered a curative approach for treating patients with severe combined immunodeficiency (SCID). However, HSCT may have long-term effects on some of these patients. This article reviews the literature regarding long-term neurocognitive function of patients who have received HSCT for SCID, including the effect of disease-specific characteristics, psychosocial factors, being a chronically ill child, and transplant-related factors.

MeSH terms

Cognition
Cognition Disorders / etiology
Hematopoietic Stem Cell Transplantation / adverse effects
Humans
Nervous System Diseases / etiology
Severe Combined Immunodeficiency / complications
Severe Combined Immunodeficiency / physiopathology
Severe Combined Immunodeficiency / psychology*
Severe Combined Immunodeficiency / therapy
Time