Synthesis, characterization and cytotoxic activities of the [RuCl2(NO)(dppp)(L)]PF6 complexes

J Inorg Biochem. 2010 May;104(5):489-95. doi: 10.1016/j.jinorgbio.2009.12.015. Epub 2010 Jan 4.

Abstract

The synthesis and characterization of ruthenium compounds of the type [RuCl(2)(NO)(dppp)(L)]PF(6) [dppp=1,3-bis(diphenylphosphino)propane; L=pyridine, 4-methylpyridine, 4-phenylpyridine and dimethyl sulfoxide] are described. The complexes were characterized by elemental analysis, UV/Vis and infrared spectroscopy, cyclic voltammetry, and X-ray crystallography for the complexes with the pyridine and 4-methylpyridine ligands. In vitro evaluation of these nitrosyl complexes revealed cytotoxic activity from 7.1 to 19.0 microM against the MDA-MB-231 breast tumor cells and showed that, in this case, they are more active than the reference metallodrug cisplatin. The 1,3-bis(diphenylphosphino)propane and the N-heterocyclic ligands alone failed to show cytotoxic activities at the concentrations tested (maximum concentration utilized=200 microM).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents* / chemical synthesis
  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / pharmacology
  • Cell Line, Tumor / drug effects*
  • Crystallography, X-Ray
  • Dimethyl Sulfoxide / chemistry
  • Drug Screening Assays, Antitumor
  • Electrochemical Techniques
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Molecular Structure
  • Phosphines / chemistry*
  • Picolines / chemistry*
  • Propane / analogs & derivatives*
  • Propane / chemistry
  • Pyridines / chemistry*
  • Ruthenium Compounds* / chemical synthesis
  • Ruthenium Compounds* / chemistry
  • Ruthenium Compounds* / pharmacology
  • Solvents / chemistry

Substances

  • Antineoplastic Agents
  • Phosphines
  • Picolines
  • Pyridines
  • Ruthenium Compounds
  • Solvents
  • 1,3-bis(diphenylphosphino)propane
  • 4-phenylpyridine
  • Propane
  • 4-methylpyridine
  • Dimethyl Sulfoxide