Boronic acid-modified DNA that changes fluorescent properties upon carbohydrate binding

Chem Commun (Camb). 2010 Feb 21;46(7):1073-5. doi: 10.1039/b921163b. Epub 2010 Jan 15.

Abstract

A long wavelength boronic acid-modified TTP (NB-TTP) has been synthesized and enzymatically incorporated into DNA. Such DNA shows intrinsic fluorescent changes upon carbohydrate addition.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Boronic Acids / chemistry*
  • DNA / chemistry*
  • DNA Polymerase I / metabolism
  • Fluorescent Dyes / chemistry*
  • Fructose / chemistry*
  • Thymine Nucleotides / chemistry

Substances

  • Boronic Acids
  • Fluorescent Dyes
  • Thymine Nucleotides
  • Fructose
  • DNA
  • DNA Polymerase I
  • thymidine 5'-triphosphate