Cyanolide A, a glycosidic macrolide with potent Molluscicidal activity from the Papua New Guinea cyanobacterium Lyngbya bouillonii

J Nat Prod. 2010 Feb 26;73(2):217-20. doi: 10.1021/np9008128.

Abstract

Over the last 50 years, molluscicides have played a critical role in the control of schistosomiasis transmission. Cyanolide A (2), isolated from extracts of a Papua New Guinea collection of Lyngbya bouillonii, is a new and highly potent molluscicidal agent against the snail vector Biomphalaria glabrata (LC(50) = 1.2 microM). The structure of cyanolide A (2) was elucidated through extensive NMR spectroscopic analyses, yielding a symmetrical dimer that represents the newest addition to the family of glycosidic macrolides from cyanobacteria.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Glucosides / chemistry
  • Glucosides / isolation & purification*
  • Glucosides / pharmacology*
  • Lyngbya Toxins / chemistry
  • Lyngbya Toxins / isolation & purification*
  • Lyngbya Toxins / pharmacology
  • Macrolides / chemistry
  • Macrolides / isolation & purification*
  • Macrolides / pharmacology*
  • Molecular Structure
  • Molluscacides / chemistry
  • Molluscacides / isolation & purification*
  • Molluscacides / pharmacology*
  • Niclosamide / chemistry
  • Niclosamide / pharmacology
  • Nuclear Magnetic Resonance, Biomolecular
  • Papua New Guinea
  • Schistosomiasis / prevention & control
  • Snails / drug effects*

Substances

  • Glucosides
  • Lyngbya Toxins
  • Macrolides
  • Molluscacides
  • cyanolide A
  • Niclosamide