Cowden syndrome

Dermatol Online J. 2010 Jan 15;16(1):7.

Abstract

Mucocutaneous papillomas can be manifestations of an autosomal dominant condition known as Cowden syndrome (CS). We report the case of a 22-year-old man with oral and cutaneous papules and a past history of thyroid malignancy. It is important to recognize oral manifestations of CS; they can lead to early diagnosis of the condition.

Publication types

  • Case Reports

MeSH terms

  • Early Diagnosis
  • Facial Dermatoses / genetics*
  • Fibroma / genetics*
  • Genes, Dominant
  • Genetic Predisposition to Disease
  • Gingival Neoplasms / genetics
  • Hamartoma Syndrome, Multiple / diagnosis*
  • Hamartoma Syndrome, Multiple / genetics
  • Humans
  • Male
  • Mouth Neoplasms / genetics*
  • Neoplasms, Multiple Primary / genetics*
  • PTEN Phosphohydrolase / deficiency
  • PTEN Phosphohydrolase / genetics
  • Thyroid Neoplasms / genetics*
  • Tongue Neoplasms / genetics
  • Young Adult

Substances

  • PTEN Phosphohydrolase
  • PTEN protein, human