Abstract
Activation of cannabinoid type-1 receptors (CB(1)) is universally recognized as a powerful endogenous orexigenic signal, but the detailed underlying neuronal mechanisms are not fully understood. Using combined genetic and pharmacological approaches in mice, we found that ventral striatal CB(1) receptors exerted a hypophagic action through inhibition of GABAergic transmission. Conversely, brain CB(1) receptors modulating excitatory transmission mediated the well-known orexigenic effects of cannabinoids.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Body Weight
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Brain / drug effects
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Brain / physiology
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Corpus Striatum / drug effects
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Corpus Striatum / physiology*
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Eating / drug effects
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Eating / physiology*
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Fasting / physiology
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Glutamic Acid / metabolism
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Mice, Transgenic
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Neural Inhibition / drug effects
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Neural Inhibition / physiology
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Neurons / drug effects
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Neurons / physiology*
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RNA, Messenger / metabolism
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Receptor, Cannabinoid, CB1 / genetics
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Receptor, Cannabinoid, CB1 / metabolism*
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Receptors, GABA-A / metabolism
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Receptors, N-Methyl-D-Aspartate / metabolism
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Synaptic Transmission / drug effects
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Synaptic Transmission / physiology
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Time Factors
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gamma-Aminobutyric Acid / metabolism
Substances
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RNA, Messenger
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Receptor, Cannabinoid, CB1
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Receptors, GABA-A
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Receptors, N-Methyl-D-Aspartate
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Glutamic Acid
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gamma-Aminobutyric Acid