Transient hepatitis B surface antigen circulation after Infanrix-Hexa: a case report and review of the literature

Eur J Pediatr. 2010 Sep;169(9):1139-41. doi: 10.1007/s00431-010-1146-2. Epub 2010 Feb 11.

Abstract

The authors describe the case of a 70-day-old boy who was mistakenly diagnosed as suffering from acute hepatitis B, when he presented with persistent unconjugated hyperbilirubinemia and transaminasemia and was found to be seropositive for the hepatitis B surface antigen. The antigenemia was transient and related to his recent immunization with Infanrix-Hexa. Caution is required during interpretation of a positive HBsAg test that is obtained within 28 days after vaccination against hepatitis B.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Disease
  • Diagnosis, Differential
  • Diphtheria-Tetanus-acellular Pertussis Vaccines / administration & dosage*
  • Diphtheria-Tetanus-acellular Pertussis Vaccines / adverse effects*
  • Haemophilus Vaccines / administration & dosage*
  • Haemophilus Vaccines / adverse effects*
  • Hepatitis B / blood
  • Hepatitis B / diagnosis
  • Hepatitis B Surface Antigens / blood*
  • Humans
  • Hyperbilirubinemia / immunology
  • Infant
  • Male
  • Poliovirus Vaccine, Inactivated / administration & dosage*
  • Poliovirus Vaccine, Inactivated / adverse effects*
  • Time Factors
  • Transaminases / blood
  • Vaccines, Combined / administration & dosage
  • Vaccines, Combined / adverse effects

Substances

  • Diphtheria-Tetanus-acellular Pertussis Vaccines
  • Haemophilus Vaccines
  • Hepatitis B Surface Antigens
  • Poliovirus Vaccine, Inactivated
  • Vaccines, Combined
  • Transaminases