Gadolinium oxide ultranarrow nanorods as multimodal contrast agents for optical and magnetic resonance imaging

Langmuir. 2010 Jun 1;26(11):8959-65. doi: 10.1021/la904751q.

Abstract

We demonstrate a simple synthetic strategy for the fabrication of single-phase rare earth (RE) doped gadolinium oxide (Gd(2)O(3):RE where RE = terbium (Tb), ytterbium (Yb), and erbium (Er)) nanorods (NRs) as multimodal imaging probes. The NRs are ultranarrow and exhibit both emission and magnetic characteristics. The Tb-doped and Yb/Er-codoped Gd(2)O(3) NRs exhibit down- and up-conversion fluorescence respectively, and also exhibit paramagnetism. Importantly, these codoped NRs possess excellent magnetic characteristics, as shown in their longitudinal relaxation time (T1) -weighted image contrast, which is closer to that of commercial Gadovist for magnetic resonance imaging (MRI) applications. This property opens up new avenues in the development of contrast agents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Contrast Media*
  • Gadolinium / chemistry*
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Microscopy, Electron, Transmission
  • Nanotubes*
  • Spectrometry, Fluorescence
  • X-Ray Diffraction

Substances

  • Contrast Media
  • gadolinium oxide
  • Gadolinium