Abstract
N-Heterocyclic carbene (NHC) platinum complexes have been highlighted as a promising and original platform for building new cytotoxic drugs of the cisplatin series. Mixed NHC-amine Pt(II) complexes have been prepared via a facile and modular two step sequence leading to trans-configured square planar species. They have been characterized by spectroscopic methods and X-ray diffraction studies. Their efficiency against both cisplatin sensitive (CEM and H460) and resistant (A2780/DDP, CH1/DDP, and SK-OV-3) cell lines has been demonstrated by in vitro experiments.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Humans
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Imidazoles / chemistry*
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Imidazoles / pharmacology
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Magnetic Resonance Spectroscopy
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Organoplatinum Compounds / chemical synthesis
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Organoplatinum Compounds / chemistry*
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Organoplatinum Compounds / pharmacology
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Structure-Activity Relationship
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X-Ray Diffraction
Substances
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Antineoplastic Agents
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Imidazoles
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Organoplatinum Compounds