Heart rate variability on 7-day Holter monitoring using a bootstrap rhythmometric procedure

IEEE Trans Biomed Eng. 2010 Jun;57(6):1366-76. doi: 10.1109/TBME.2010.2040899. Epub 2010 Feb 17.

Abstract

Heart rate variability (HRV) markers have been widely used to characterize the autonomous regulation state of the heart from 24-h Holter monitoring, but long-term evolution of HRV indexes is mostly unknown. A dataset of 7-day Holter recordings of 22 patients with congestive heart failure was studied. A rhythmometric procedure was designed to characterize the infradian, circadian, and ultradian components for each patient, as well as circadian and ultradian fluctuations. Furthermore, a bootstrap test yielded automatically the rhythmometric model for each patient. We analyzed the temporal evolution of relevant time-domain (AVNN, SDNN, and NN50), frequency-domain (LF, HF, HFn, and LF/HF), and nonlinear (alpha(1) and SampEn) HRV indexes. Circadian components were the most significant for all HRV indexes, but the infradian ones were also strongly present in NN50, HFn, LF/HF, alpha(1), and SampEn indexes. Among ultradian components that one corresponding to 12 h, was the most relevant. Long-term monitoring of HRV conveys new potentially relevant rhythmometric information, which can be analyzed by using the proposed automatic procedure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Arrhythmias, Cardiac / diagnosis*
  • Arrhythmias, Cardiac / physiopathology*
  • Circadian Rhythm*
  • Diagnosis, Computer-Assisted / methods*
  • Electrocardiography, Ambulatory / methods*
  • Heart Rate*
  • Humans
  • Oscillometry / methods
  • Periodicity*
  • Reproducibility of Results
  • Sensitivity and Specificity