Tremor: a newly described adverse event with long-term itraconazole therapy

J Neurol Neurosurg Psychiatry. 2010 Mar;81(3):327-9. doi: 10.1136/jnnp.2009.174706.

Abstract

Itraconazole is a widely prescribed triazole antifungal drug, often given for long periods. The authors report five cases of tremor related to itraconazole therapy, which occurred within 1-12 months of initiating treatment and resolved gradually following itraconazole withdrawal.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antifungal Agents / adverse effects*
  • Antifungal Agents / pharmacokinetics
  • Antifungal Agents / therapeutic use
  • Aspergillosis, Allergic Bronchopulmonary / blood
  • Aspergillosis, Allergic Bronchopulmonary / drug therapy*
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Itraconazole / adverse effects*
  • Itraconazole / pharmacokinetics
  • Itraconazole / therapeutic use
  • Long-Term Care
  • Male
  • Middle Aged
  • Mycobacterium Infections, Nontuberculous / blood
  • Mycobacterium Infections, Nontuberculous / drug therapy*
  • Pulmonary Aspergillosis / blood
  • Pulmonary Aspergillosis / drug therapy*
  • Tremor / blood
  • Tremor / chemically induced*

Substances

  • Antifungal Agents
  • Itraconazole