Abstract
New natural products for drug discovery may be accessed by heterologous expression of bacterial biosynthetic pathways in metagenomic DNA libraries. However, a "universal" host is needed for this experiment. Herein, we show that Myxococcus xanthus is a potential "universal" host for heterologous expression of polyketide biosynthetic gene clusters.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / biosynthesis*
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Bacterial Proteins / genetics*
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Biosynthetic Pathways / genetics*
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Gene Order
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Multigene Family
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Myxococcus xanthus / genetics*
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Oxytetracycline / biosynthesis*
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Recombinant Proteins / biosynthesis
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Recombinant Proteins / genetics
Substances
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Bacterial Proteins
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Recombinant Proteins
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Oxytetracycline