Extraocular manifestations of birdshot chorioretinopathy in 118 French patients

Presse Med. 2010 May;39(5):e97-e102. doi: 10.1016/j.lpm.2009.12.005. Epub 2010 Mar 10.

Abstract

Introduction: Published studies on birdshot chorioretinopathy (BCR) did not provide definitive information on possibly associated extraocular manifestations.

Methods: Single-center cross-sectional analysis of extraocular manifestations in a cohort of patients with BCR.

Results: Since 2002, 118 patients (45 men, 73 women) were enrolled. Their mean age was 51.5 years at diagnosis. The most common features of their medical histories were: hypertension (32 patients), drug allergy (19), sinusitis (17), thyroid disease (12), otitis media (11), asthma (11); diabetes (10); cancer (8); psoriasis (5); monoclonal gammopathies (3). At the time of disease onset, arthralgias were noted in 23, ENT manifestations in 26, Raynaud's phenomenon in 6, headaches in 10, psoriasis in 3 others. Between diagnosis and cross-sectional evaluation visits, only the frequency of hypertension has increased significantly (11 additional patients).

Discussion and conclusions: No predominant extraocular manifestation of BCR was identified in our patients. Their ongoing follow-up may yet discern whether BCR is definitively eye-restricted.

MeSH terms

  • Arthralgia / diagnosis
  • Asthma / diagnosis
  • Choroid Diseases / diagnosis
  • Chronic Disease
  • Cohort Studies
  • Cross-Sectional Studies
  • Diabetes Mellitus / diagnosis
  • Female
  • France
  • HLA-A Antigens / analysis
  • Hearing Disorders / diagnosis
  • Humans
  • Hypersensitivity / diagnosis
  • Hypertension / diagnosis
  • Longitudinal Studies
  • Male
  • Medical History Taking
  • Middle Aged
  • Mood Disorders / diagnosis
  • Otitis Media / diagnosis
  • Sinusitis / diagnosis
  • Smoking
  • Thyroid Diseases / diagnosis
  • Uveitis, Posterior / diagnosis*

Substances

  • HLA-A Antigens
  • HLA-A29 antigen