First case of genotype 4 human hepatitis E virus infection acquired in India

K J Rolfe; M D Curran; N Mangrolia; W Gelson; G J M Alexander; M L'estrange; R Vivek; R Tedder; S Ijaz

doi:10.1016/j.jcv.2010.02.004

First case of genotype 4 human hepatitis E virus infection acquired in India

J Clin Virol. 2010 May;48(1):58-61. doi: 10.1016/j.jcv.2010.02.004. Epub 2010 Mar 15.

Authors

K J Rolfe¹, M D Curran, N Mangrolia, W Gelson, G J M Alexander, M L'estrange, R Vivek, R Tedder, S Ijaz

Affiliation

¹ Clinical Microbiology and Public Health Laboratory, Health Protection Agency, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QW, UK. Kathryn.rolfe@addenbrookes.nhs.uk

PMID: 20227909
DOI: 10.1016/j.jcv.2010.02.004

Abstract

This report describes a case of severe hepatitis in an individual returning from India which was found to be the result of infection with HEV genotype 4. HEV was diagnosed using a novel RT-PCR assay (with internal control) for HEV RNA detection/quantitation, described herein. This is the first documented report of zoonotic transmission of HEV genotype 4 infection acquired in India.

Publication types

Case Reports

MeSH terms

Aged
Animals
Genotype
Hepatitis E / virology*
Hepatitis E virus / genetics*
Humans
India
Liver Function Tests
Male
Phylogeny
RNA, Viral / blood
Reverse Transcriptase Polymerase Chain Reaction
Swine
Zoonoses / virology*

Substances

RNA, Viral