Maduropeptin, a complex of new macromolecular antitumor antibiotics

J Antibiot (Tokyo). 1991 Apr;44(4):403-14. doi: 10.7164/antibiotics.44.403.

Abstract

Maduropeptin, a complex of new macromolecular antitumor antibiotics, is a metabolite of Actinomadura madurae H710-49. The active components maduropeptins A1, A2 and B are acidic chromopeptides with MW of around 22,500 and composed of 14 types of amino acids and an unstable chromophore. The antibiotics are active in vitro against Gram-positive bacteria and highly cytotoxic to tumor cells. They produced significant prolongation of survival time of mice implanted with P388 leukemia and B16 melanoma.

MeSH terms

  • Actinomyces / metabolism
  • Amino Acids / analysis
  • Animals
  • Anti-Bacterial Agents*
  • Antibiotics, Antineoplastic / biosynthesis
  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / therapeutic use*
  • Antimicrobial Cationic Peptides
  • Chromatography, High Pressure Liquid
  • Drug Stability
  • Enediynes
  • Female
  • Gram-Positive Bacteria / drug effects
  • Leukemia P388 / drug therapy
  • Male
  • Melanoma, Experimental / drug therapy
  • Mice
  • Molecular Weight
  • Peptide Biosynthesis
  • Peptides / chemistry
  • Peptides / therapeutic use
  • Photochemistry

Substances

  • Amino Acids
  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Antimicrobial Cationic Peptides
  • Enediynes
  • Peptides
  • maduropeptin A1
  • maduropeptin A2
  • maduropeptin B
  • maduropeptin C