[Pharmacokinetics of biological tags in a case of acute valpromide self poisoning]

Ann Biol Clin (Paris). 2010 Mar-Apr;68(2):234-8. doi: 10.1684/abc.2010.0421.
[Article in French]

Abstract

We report the case of a 35-year-old woman hospitalized in intensive care unit after valpromide self-poisoning (Dépamide). The dose supposed to be taken was 15 g. The patient eleven hours after ingestion, presented, a coma with bilateral non-reactive mydriasis, justifying intubation and mechanical ventilation. An acidosis (pH = 7.24), a hyperlactatemia (2.72 mmol/L), a hyperammonemia (328.9 micromol/L), and were diagnosed valproic acid plasmatic concentration was 1190 microg/mL at 22 hours. Symptomatic treatment and L-carnitine therapy (50 mg/kg/12h) normalized the action of biological abnormalities and allowed disappearance of symptoms; the patient was extubated after 46 hours, and outcome from intensive care unit at 65 hours.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Acidosis / chemically induced
  • Adult
  • Ammonia / blood
  • Anticonvulsants / poisoning*
  • Carnitine / therapeutic use
  • Female
  • Humans
  • Lactates / blood
  • Poisoning / blood*
  • Respiration, Artificial
  • Time Factors
  • Treatment Outcome
  • Valproic Acid / analogs & derivatives*
  • Valproic Acid / blood
  • Valproic Acid / pharmacokinetics
  • Valproic Acid / poisoning

Substances

  • Anticonvulsants
  • Lactates
  • Valproic Acid
  • Ammonia
  • dipropylacetamide
  • Carnitine