Intracellular penetration and activity of UB-8902 in human polymorphonuclear leukocytes

Sofía Ballesta; Isabel García; Javier Sánchez-Céspedez; Jordi Vila; Alvaro Pascual

doi:10.1016/j.eimc.2009.11.014

Intracellular penetration and activity of UB-8902 in human polymorphonuclear leukocytes

Enferm Infecc Microbiol Clin. 2010 Nov;28(9):612-4. doi: 10.1016/j.eimc.2009.11.014. Epub 2010 Apr 24.

Authors

Sofía Ballesta¹, Isabel García, Javier Sánchez-Céspedez, Jordi Vila, Alvaro Pascual

Affiliation

¹ Departmento de Microbiología, Facultad de Medicina, Universidad de Sevilla, Seville, Spain. mudarra@us.es

PMID: 20417992
DOI: 10.1016/j.eimc.2009.11.014

Abstract

The intracellular penetration and activity of UB-8902 in human polymorphonuclear leukocytes was evaluated. Intracellular UB-8902 concentrations were 6-fold higher than extracellular levels. Uptake was rapid, reversible, saturable, and affected by external pH. UB-8902 showed intracellular activity against Staphylococcus aureus strains presenting mutations associated with fluoroquinolone resistance in the gyrA and/or grlA genes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / pharmacokinetics*
Ciprofloxacin / analogs & derivatives*
Ciprofloxacin / pharmacokinetics
Humans
Neutrophils / metabolism*

Substances

Anti-Infective Agents
UB 8902
Ciprofloxacin