Developing an anion host for lipid A binding and antibacterial activity

Chem Commun (Camb). 2010 May 14;46(18):3197-9. doi: 10.1039/b925135a. Epub 2010 Mar 18.

Abstract

New structural amphiphiles 2a and 2b bind the diphosphate lipid A anion and show potential as lead compounds for the development of novel antibacterial agents.

MeSH terms

  • Acinetobacter Infections / drug therapy
  • Acinetobacter baumannii / drug effects
  • Anions / chemistry
  • Anions / metabolism
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology*
  • Erythrocytes / drug effects
  • Gram-Negative Bacteria / drug effects*
  • Humans
  • Lipid A / chemistry
  • Lipid A / metabolism*
  • Microbial Sensitivity Tests
  • Models, Molecular
  • Pseudomonas Infections / drug therapy
  • Pseudomonas aeruginosa / drug effects
  • Surface-Active Agents / chemistry*
  • Surface-Active Agents / pharmacology*

Substances

  • Anions
  • Anti-Bacterial Agents
  • Lipid A
  • Surface-Active Agents