Synthesis and antitumor evaluation of a novel class of 4-substituted-1,4-dihydroisoquinolin-3-ones

Ting Ma; Wenteng Chen; Guolin Zhang; Yongping Yu

doi:10.1021/cc100021t

Synthesis and antitumor evaluation of a novel class of 4-substituted-1,4-dihydroisoquinolin-3-ones

J Comb Chem. 2010 Jul 12;12(4):488-90. doi: 10.1021/cc100021t.

Authors

Ting Ma¹, Wenteng Chen, Guolin Zhang, Yongping Yu

Affiliation

¹ Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China.

PMID: 20426396
DOI: 10.1021/cc100021t

Abstract

An efficient method for the solution-phase parallel synthesis of 4-substituted-1,4-dihydroisoquinolin-3-ones is developed. The isoquinolinones were constructed employing an intramolecular Heck reaction, providing full regio- and stereoselectivity. Most of the synthesized compounds showed potent antiproliferative activities against tumor cell lines.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Antiprotozoal Agents / chemical synthesis
Antiprotozoal Agents / chemistry
Antiprotozoal Agents / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Combinatorial Chemistry Techniques
Drug Screening Assays, Antitumor
Humans
Isoquinolines / chemical synthesis
Isoquinolines / chemistry
Isoquinolines / pharmacology*
Molecular Structure
Small Molecule Libraries
Stereoisomerism

Substances

Antiprotozoal Agents
Isoquinolines
Small Molecule Libraries