New dirhodium complex with activity towards colorectal cancer

Bioorg Med Chem Lett. 2010 Jun 1;20(11):3413-5. doi: 10.1016/j.bmcl.2010.04.002. Epub 2010 Apr 9.

Abstract

A novel dirhodium complex (Rh(2)(L-PheAla)(2)(OAc)(2) is reported with strong activity towards human colon adenocarcinoma cells. Its effect was not accompanied by generation of reactive oxygen species (ROS) neither by activation of caspase-3.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / enzymology
  • Adenocarcinoma / metabolism
  • Adenocarcinoma / pathology*
  • Caspase 3 / metabolism
  • Colorectal Neoplasms / enzymology
  • Colorectal Neoplasms / metabolism
  • Colorectal Neoplasms / pathology*
  • Enzyme Activation
  • Humans
  • Reactive Oxygen Species / metabolism
  • Rhodium / pharmacology*

Substances

  • Reactive Oxygen Species
  • Rhodium
  • Caspase 3