Abstract
Bioassay guided fractionation of the hydro-alcoholic extract of the fruits of Capparis moonii, led to the isolation of two new chebulinic acid derivatives. The compounds 1 and 2 displayed significant glucose uptake effect of 223% and 219% over the control at the 10ng/ml and 100ng/ml concentration, respectively. The increased glucose uptake effects of the compounds were associated with significant IR and IRS-1 phosphorylation, GLUT4 and PI3-kinase mRNA expression in the L6 cells.
MeSH terms
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Animals
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Capparis / chemistry*
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Cell Line
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Glucose / metabolism*
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Glucose Transporter Type 4 / genetics
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Hydrolyzable Tannins / isolation & purification*
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Hydrolyzable Tannins / pharmacology*
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Insulin Receptor Substrate Proteins / metabolism
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Molecular Mimicry
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Phosphatidylinositol 3-Kinases / genetics
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Phosphorylation / drug effects
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Phytotherapy
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RNA, Messenger / analysis
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RNA, Messenger / drug effects
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Rats
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Receptor, Insulin / metabolism
Substances
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Glucose Transporter Type 4
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Hydrolyzable Tannins
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Insulin Receptor Substrate Proteins
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RNA, Messenger
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Phosphatidylinositol 3-Kinases
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Receptor, Insulin
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Glucose