Abstract
Three adult patients, two with undifferentiated connective tissue disease and one with carcinoma, had a distinctive pathologic reaction pattern consisting of necrotizing myopathy, minimal cellular infiltration, and a microangiopathy with thick "pipestem" vessels and microvascular deposits of complement membrane attack complex. Quantitative analysis revealed focal capillary depletion. This pattern represents an immune-mediated microangiopathy and is distinct from that observed in other inflammatory myopathies.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Carcinoma, Transitional Cell / pathology
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Carcinoma, Transitional Cell / therapy
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Complement Membrane Attack Complex / immunology*
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Connective Tissue Diseases / immunology
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Connective Tissue Diseases / pathology*
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Endothelium, Vascular / ultrastructure
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Female
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Humans
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Immunohistochemistry
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Immunotherapy
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Male
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Microscopy, Electron
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Middle Aged
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Muscles / blood supply
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Muscles / pathology
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Muscles / ultrastructure
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Muscular Diseases / pathology*
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Necrosis
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Urinary Bladder Neoplasms / pathology
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Urinary Bladder Neoplasms / therapy
Substances
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Complement Membrane Attack Complex