Signal integration through blending, bolstering and bifurcating of intracellular information

Catherine T Pawson; John D Scott

doi:10.1038/nsmb.1843

Signal integration through blending, bolstering and bifurcating of intracellular information

Nat Struct Mol Biol. 2010 Jun;17(6):653-8. doi: 10.1038/nsmb.1843. Epub 2010 May 23.

Authors

Catherine T Pawson¹, John D Scott

Affiliation

¹ Howard Hughes Medical Institute, Department of Pharmacology, University of Washington, School of Medicine, Seattle, Washington, USA.

Abstract

A cell's response to its environment is often determined by signaling through the actions of enzyme cascades. The ability to organize these enzymes into multiprotein complexes allows for a high degree of fidelity, efficiency and spatial precision in signaling responses.

Publication types

Review

MeSH terms

Animals
Enzymes / metabolism
Humans
Intracellular Signaling Peptides and Proteins / metabolism
Intracellular Space / metabolism
Models, Biological
Multienzyme Complexes / metabolism
Signal Transduction / physiology*

Substances

Enzymes
Intracellular Signaling Peptides and Proteins
Multienzyme Complexes

Abstract

Publication types

MeSH terms

Substances

Grants and funding