Liquid chromatographic analysis of a potential polymeric-pendant drug delivery system for peptides. Application of high-performance size-exclusion chromatography, reversed-phase high-performance liquid chromatography and ion chromatography to the evaluation of biodegradable poly[(chloromethoxytrialanine methyl ester)phosphazenes]

J Chromatogr. 1991 Jan 4;536(1-2):255-64. doi: 10.1016/s0021-9673(01)89258-x.

Abstract

A novel water-soluble polymer, poly[(chloromethoxytrialanine methyl ester)phosphazene] (poly-Tame), was characterized and evaluated using high-performance size-exclusion chromatography, gradient reversed-phase high-performance liquid chromatography and ion chromatography. These novel liquid chromatographic methods were validated for application to in vitro biodegradation experiments of poly-Tame in aqueous solutions. Results from method validation experiments are presented.

MeSH terms

  • Biodegradation, Environmental
  • Chromatography, Gel
  • Chromatography, High Pressure Liquid
  • Drug Carriers*
  • Hydrogen-Ion Concentration
  • Ions
  • Organophosphorus Compounds / analysis*
  • Peptides / administration & dosage*
  • Polymers* / analysis*
  • Spectrophotometry, Ultraviolet

Substances

  • Drug Carriers
  • Ions
  • Organophosphorus Compounds
  • Peptides
  • Polymers
  • poly(chloromethoxytrialanine methyl ester)phosphazene