Wrapping up stereocilia rootlets

Jacques Boutet de Monvel; Christine Petit

doi:10.1016/j.cell.2010.05.022

Wrapping up stereocilia rootlets

Cell. 2010 May 28;141(5):748-50. doi: 10.1016/j.cell.2010.05.022.

Authors

Jacques Boutet de Monvel¹, Christine Petit

Affiliation

¹ Unité de Génétique et Physiologie de l'Audition, Département de Neuroscience, Institut Pasteur, 75724 Paris Cedex 15, France; Inserm UMRS 587, Paris, France.

PMID: 20510920
DOI: 10.1016/j.cell.2010.05.022

Abstract

The actin-filled stereocilia of cochlear hair cells deflect in response to sound by pivoting around rootlets at their insertion points at the sensory cell surface. Kitajiri et al. (2010) now show that the actin-binding protein TRIOBP tightly bundles the actin filaments into rootlets, endowing these stereocilia "pivots" with unique elasticity and robustness.

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