Arylthioureas with bromine or its equivalents gives no 'Hugerschoff' reaction product

Org Biomol Chem. 2010 Aug 7;8(15):3389-93. doi: 10.1039/c003892j. Epub 2010 Jun 16.

Abstract

The in situ generated aryl-alkyl unsymmetrical thiourea obtained by the reaction of an aryl isothiocyanate with an aliphatic secondary amine on treatment with bromine or its equivalent gave exclusively a product having a thioamido guanidino moiety and not the expected Hugerschoff product 2-aminobenzothiazole. A plausible reaction mechanism has been proposed for this unprecedented transformation and the scope has been extended to various substrates.