Visceral involvements and long-term sequelae in drug-induced hypersensitivity syndrome

Yoko Kano; Tadashi Ishida; Kazuhisa Hirahara; Tetsuo Shiohara

doi:10.1016/j.mcna.2010.03.004

Visceral involvements and long-term sequelae in drug-induced hypersensitivity syndrome

Med Clin North Am. 2010 Jul;94(4):743-59, xi. doi: 10.1016/j.mcna.2010.03.004.

Authors

Yoko Kano¹, Tadashi Ishida, Kazuhisa Hirahara, Tetsuo Shiohara

Affiliation

¹ Department of Dermatology, Kyorin University School of Medicine, 6-20-2 Shinkawa Mitaka, Tokyo 181-8611, Japan. kano@ks.kyorin-u.ac.jp

PMID: 20609861
DOI: 10.1016/j.mcna.2010.03.004

Abstract

Drug-induced hypersensitivity syndrome (DIHS) is a severe systemic reaction with several herpesvirus reactivations. Multiple organ failures appear during the course of the disease. The severity of DIHS is determined by the degree of visceral involvement. Autoimmune diseases also develop several months to years after the apparent clinical resolution of DIHS.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Autoimmune Diseases / chemically induced*
Chemical and Drug Induced Liver Injury / diagnosis
Chemical and Drug Induced Liver Injury / etiology
Diabetes Mellitus, Type 1 / chemically induced
Digestive System Diseases / chemically induced*
Digestive System Diseases / etiology
Drug Hypersensitivity / complications*
Drug Hypersensitivity / diagnosis
Heart Diseases / chemically induced
Herpesviridae / physiology
Herpesviridae Infections / chemically induced
Herpesviridae Infections / virology
Kidney Diseases / chemically induced
Lung Diseases / chemically induced
Lupus Erythematosus, Systemic / chemically induced
Meningoencephalitis / chemically induced
Multiple Organ Failure / chemically induced*
Multiple Organ Failure / virology
Risk Factors
Scleroderma, Systemic / chemically induced
Syndrome
Thyroiditis / chemically induced
Time Factors
Virus Activation