Thalamic neurochemical abnormalities in individuals with prodromal symptoms of schizophrenia - relationship to auditory event-related potentials

Psychiatry Res. 2010 Aug 30;183(2):174-6. doi: 10.1016/j.pscychresns.2010.05.004.

Abstract

Thalamic neurochemical abnormalities may underlie psychotic symptoms and auditory event-related potential (ERP) abnormalities in schizophrenia. We investigated this hypothesis in subjects at risk of psychosis using magnetic resonance spectroscopy and electroencephalography (EEG). Reduced thalamic glutamate plus glutamine and N-acetyl aspartate levels were associated with abnormal frontal ERPs, supporting a thalamic basis for filtering impairments.

MeSH terms

  • Acoustic Stimulation / methods
  • Adult
  • Aspartic Acid / analogs & derivatives
  • Aspartic Acid / metabolism
  • Electroencephalography
  • Evoked Potentials, Auditory / physiology*
  • Female
  • Frontal Lobe / physiopathology
  • Glutamic Acid / metabolism
  • Glutamine / metabolism
  • Humans
  • Linear Models
  • Magnetic Resonance Spectroscopy / methods
  • Male
  • Neurochemistry*
  • Protons
  • Radionuclide Imaging
  • Schizophrenia / diagnostic imaging
  • Schizophrenia / pathology*
  • Schizophrenia / physiopathology
  • Thalamus / metabolism*
  • Young Adult

Substances

  • Protons
  • Glutamine
  • Aspartic Acid
  • Glutamic Acid
  • N-acetylaspartate