A DOTA-peptide conjugate by copper-free click chemistry

Bioorg Med Chem Lett. 2010 Aug 15;20(16):4805-7. doi: 10.1016/j.bmcl.2010.06.111. Epub 2010 Jun 25.

Abstract

Attachment of DOTA to a novel monofluoro-cyclooctyne facilitates bioconjugation to an azide-modified peptide via Cu-free click chemistry. The resulting conjugate was radiolabeled with (111)In to afford a potential targeted molecular imaging agent with high specific activity and an excellent radiochemical purity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Copper / chemistry
  • Heterocyclic Compounds, 1-Ring / chemistry*
  • Humans
  • Indium Radioisotopes / chemistry
  • Neuroblastoma / diagnostic imaging
  • Peptides / chemistry*
  • Radiography
  • Radiopharmaceuticals / chemical synthesis
  • Radiopharmaceuticals / chemistry*

Substances

  • Heterocyclic Compounds, 1-Ring
  • Indium Radioisotopes
  • Peptides
  • Radiopharmaceuticals
  • 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
  • Copper