Polymorphisms in the AR and PSA genes as markers of susceptibility and aggressiveness in prostate cancer

Cancer Invest. 2010 Nov;28(9):917-24. doi: 10.3109/07357907.2010.483509.

Abstract

The study of genes involved in androgen pathway can contribute to a better knowledge of prostate cancer. Our aim was to examine if polymorphisms in prostate-specific antigen (PSA) and androgen receptor (AR) genes were involved in prostate cancer risk and aggressiveness. Genotypes were determined by PCR-RFLP (PSA) or using a 377 ABI DNA Sequencer (AR). PSA(G/G) genotype (OR = 1.78, 95% CI = 1.06–2.99) and AR short CAG repeats (OR = 1.89, 95% CI = 1.21–2.96) increased risk for prostate cancer and were related with tumor aggressiveness. About 38.3% of tumors showed microsatellite instability. In conclusion, polymorphisms in these genes may be indicated as potential biomarkers for prostate cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alleles
  • Biomarkers, Tumor / analysis
  • Biomarkers, Tumor / genetics
  • Gene Frequency
  • Genetic Predisposition to Disease / genetics
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Polymorphism, Restriction Fragment Length
  • Prostate-Specific Antigen / genetics*
  • Prostatic Neoplasms / genetics*
  • Prostatic Neoplasms / pathology
  • Receptors, Androgen / genetics*
  • Sequence Analysis, DNA
  • Trinucleotide Repeats / genetics

Substances

  • Biomarkers, Tumor
  • Receptors, Androgen
  • Prostate-Specific Antigen