Regulation of GSK3 isoforms by phosphatases PP1 and PP2A

Mol Cell Biochem. 2010 Nov;344(1-2):211-5. doi: 10.1007/s11010-010-0544-0. Epub 2010 Jul 22.

Abstract

Dephosphorylation of phospho GSK3 isoforms, from COS-7 cells, was determined in vitro and in cultured cells in the absence or the presence of okadaic acid and lithium. Our results indicate a preferential dephosphorylation of phospho GSK3α by PP2A phosphatase, whereas dephosphorylation of phospho GSK3β mainly takes place by PP1 phosphatase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • COS Cells
  • Chlorocebus aethiops
  • Glycogen Synthase Kinase 3 / metabolism*
  • Isoenzymes / metabolism*
  • Phosphoprotein Phosphatases / metabolism*
  • Phosphorylation

Substances

  • Isoenzymes
  • Glycogen Synthase Kinase 3
  • Phosphoprotein Phosphatases