Synthesis of complex allylic esters via C-H oxidation vs C-C bond formation

J Am Chem Soc. 2010 Aug 18;132(32):11323-8. doi: 10.1021/ja104826g.

Abstract

A highly general, predictably selective C-H oxidation method for the direct, catalytic synthesis of complex allylic esters is introduced. This Pd(II)/sulfoxide-catalyzed method allows a wide range of complex aryl and alkyl carboxylic acids to couple directly with terminal olefins to furnish (E)-allylic esters in synthetically useful yields and selectivities (16 examples, E/Z >or= 10:1) and without the use of stoichiometric coupling reagents or unstable intermediates. Strategic advantages of constructing allylic esters via C-H oxidation vs C-C bond-forming methods are evaluated and discussed in four "case studies".

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemical synthesis*
  • Alkenes / chemistry*
  • Carbon / chemistry*
  • Carboxylic Acids / chemistry
  • Catalysis
  • Esters
  • Hydrogen / chemistry*
  • Oxidation-Reduction
  • Stereoisomerism
  • Substrate Specificity

Substances

  • Alkenes
  • Carboxylic Acids
  • Esters
  • Carbon
  • Hydrogen