Discovery of a novel Hsp90 inhibitor by fragment linking

ChemMedChem. 2010 Oct 4;5(10):1697-700. doi: 10.1002/cmdc.201000219.
No abstract available

MeSH terms

  • Adenine / analogs & derivatives*
  • Adenine / chemical synthesis
  • Adenine / chemistry
  • Adenine / pharmacology
  • Binding Sites
  • Computer Simulation
  • Drug Evaluation, Preclinical
  • HSP90 Heat-Shock Proteins / antagonists & inhibitors*
  • HSP90 Heat-Shock Proteins / metabolism
  • Pyrazoles / chemical synthesis
  • Pyrazoles / chemistry*
  • Pyrazoles / pharmacology
  • Thermodynamics

Substances

  • (4-(5-furan-2-yl-3-methyl-1H-pyrazol-4-yl)-butyl)methyl-(7H-purin-6-yl)amine
  • HSP90 Heat-Shock Proteins
  • Pyrazoles
  • Adenine