[A case of localized malignant pleural mesothelioma]

Nihon Kokyuki Gakkai Zasshi. 2010 Jul;48(7):511-5.
[Article in Japanese]

Abstract

A 74-year-old man was referred to our hospital for examination of an abnormal chest shadow. A chest computed tomography (CT) scan revealed a 5-cm mass attached to the pleura involving the right upper lobe, and a nodule in the right middle lobe. Transbronchial lung biopsy was performed twice, but no definitive diagnosis was achieved. 18-fluorodeoxyglucose positron emission tomography showed abnormal uptake in the chest lesion. Chemotherapy was initiated for advanced-stage lung cancer, but was not effective. Histopathologic and immunohistochemical examinations after CT-guided needle biopsy revealed malignant mesothelioma. The tumor cells were positive for calretinin and thrombomodulin, and negative for CEA, TTF-1, and SP-A. There was local tumor invasion and metastasis in the lung and brain, without diffuse pleural spread. This is a rare and important case of localized malignant mesothelioma pathologically confirmed by biopsy.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Humans
  • Male
  • Pleural Neoplasms / pathology*
  • Solitary Fibrous Tumor, Pleural / pathology*