Abstract
Minocycline is a clinically available antibiotic and anti-inflammatory drug that also demonstrates neuroprotective properties in a variety of experimental models of neurological diseases. There have thus far been more than 300 publications on minocycline neuroprotection, including a growing number of human studies. Our objective is to critically review the biological basis and translational potential of this action of minocycline on the nervous system.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Clinical Trials as Topic / methods
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Clinical Trials as Topic / statistics & numerical data
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Disease Models, Animal
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Humans
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Minocycline / pharmacology
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Minocycline / therapeutic use*
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Nervous System Diseases / drug therapy*
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Neuroprotective Agents / pharmacology
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Neuroprotective Agents / therapeutic use*
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Signal Transduction / drug effects
Substances
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Neuroprotective Agents
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Minocycline