Abstract
The enzymatic glycosylation of microarrays is a relatively young field in glycoscience. Platforms developed from other array technologies (e.g., proteins and nucleic acids) were successfully adopted in several proof-of-principle studies as a high-throughput tool for the generation of more complex carbohydrate structures using carbohydrate-processing enzymes. These arrays and the developed on-chip enzymatic glycosylation methodologies are reviewed in this article.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antibodies / metabolism
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Carbohydrate Conformation
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Carbohydrate Sequence
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Carbohydrates / chemistry*
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Enzymes / metabolism*
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Glycomics / instrumentation
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Glycomics / methods*
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Glycosylation
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Molecular Sequence Data
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Molecular Structure
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Oligonucleotide Array Sequence Analysis / methods*
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
Substances
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Antibodies
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Carbohydrates
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Enzymes